Scientific Studies

(1) Meyers KJ, Mares JA, Igo RP Jr et al: Genetic evidence for role of carotenoids in age-related macular degeneration in the Carotenoids in Age-Related Eye Disease Study (CAREDS). Invest Ophthalmol Vis Sci. 2014 Jan 29; 55(1):587-99.


(2) Age-Related Eye Disease Study 2 (AREDS2) Research Group, Chew EY, Clemons TE, Sangiovanni JP et al: Secondary analyses of the effects of lutein/zeaxanthin on age-related macular degeneration progression: AREDS2 report No. 3. JAMA Ophthalmol. 2014 Feb; 132(2):142-9.


(3) Wang JJ, Buitendijk GH, Rochtchina E et al: Genetic susceptibility, dietary antioxidants, and long-term incidence of age-related macular degeneration in two populations. Ophthalmology. 2014 Mar; 121(3):667-75.


(4) Kesse-Guyot E, Andreeva VA, Ducros V et al: Carotenoid-rich dietary patterns during midlife and subsequent cognitive function. Br J Nutr. 2014 Mar 14; 111(5):915-23.


(5) Zou ZY, Xu XR, Lin XM et al: Effects of lutein and lycopene on carotid intima-media thickness in Chinese subjects with subclinical atherosclerosis: a randomised, double-blind, placebo-controlled trial. Br J Nutr. 2014 Feb; 111(3):474-80.


(6) Slattery ML, Lundgreen A, Wolff RK: Dietary influence on MAPK-signaling pathways and risk of colon and rectal cancer. Nutr Cancer. 2013; 65(5):729-38.


(7) Lorenzoni F, Giampietri M, Ferri G: Lutein administration to pregnant women with gestational diabetes mellitus is associated to a decrease of oxidative stress in newborns. Gynecol Endocrinol. 2013 Oct; 29(10):901-3.


(8) Wang MX, Jiao JH, Li ZY et al: Lutein supplementation reduces plasma lipid peroxidation and C-reactive protein in healthy nonsmokers. Atherosclerosis. 2013 Apr; 227(2):380-5.


(9) Murray IJ, Makridaki M, van der Veen RL et al: Lutein supplementation over a one-year period in early AMD might have a mild beneficial effect on visual acuity: the CLEAR study. Invest Ophthalmol Vis Sci. 2013 Mar 11; 54(3):1781-8.


(10) Yao Y, Qiu QH, Wu XW et al: Lutein supplementation improves visual performance in Chinese drivers: 1-year randomized, double-blind, placebo-controlled study. Nutrition. 2013 Jul-Aug; 29(7-8):958-64.


(11) Huang YM, Yan SF, Ma L et al: Serum and macular responses to multiple xanthophyll supplements in patients with early age-related macular degeneration. Nutrition. 2013 Feb; 29(2):387-92.


(12) Meinke MC, Friedrich A, Tscherch K et al: Influence of dietary carotenoids on radical scavenging capacity of the skin and skin lipids. Eur J Pharm Biopharm. 2013 Jun; 84(2):365-73.


(13) Beatty S, Chakravarthy U, Nolan JM et al: Secondary outcomes in a clinical trial of carotenoids with coantioxidants versus placebo in early age-related macular degeneration. Ophthalmology. 2013 Mar; 120(3):600-6.


(14) Xu XR, Zou ZY, Xiao X et al: Effects of lutein supplement on serum inflammatory cytokines, ApoE and lipid profiles in early atherosclerosis population. J Atheroscler Thromb. 2013 Feb 22; 20(2):170-7.


(15) Berrow EJ, Bartlett HE, Eperjesi F et al: The effects of a lutein-based supplement on objective and subjective measures of retinal and visual function in eyes with age-related maculopathy – a randomized controlled trial. Br J Nutr. 2013 Jun; 109(11):2008-14.


(16) Ros MM, Bueno-de-Mesquita HB, Kampman E et al: Plasma carotenoids and vitamin C concentrations and risk of urothelial cell carcinoma in the European Prospective Investigation into Cancer and Nutrition. Am J Clin Nutr. 2012 Oct; 96(4):902-10.


(17) Ma L, Yan SF, Huang YM et al: Effect of lutein and zeaxanthin on macular pigment and visual function in patients with early age-related macular degeneration. Ophthalmology. 2012 Nov; 119(11):2290-7.


(18) Ma L, Dou HL, Huang YM et al: Improvement of retinal function in early age-related macular degeneration after lutein and zeaxanthin supplementation: a randomized, double-masked, placebo-controlled trial. Am J Ophthalmol. 2012 Oct; 154(4):625-634.


(19) Giaconi JA, Yu F, Stone KL et al: The association of consumption of fruits/vegetables with decreased risk of glaucoma among older African-American women in the study of osteoporotic fractures. Am J Ophthalmol. 2012 Oct; 154(4):635-44.


(20) Manzoni P, Guardione R, Bonetti P et al: Lutein and zeaxanthin supplementation in preterm very low-birthweight neonates in neonatal intensive care units: a multicenter randomized controlled trial. Am J Perinatol. 2013 Jan; 30(1):25-32.


(21) Tanito M, Obana A, Gohto Y et al: Macular pigment density changes in Japanese individuals supplemented with lutein or zeaxanthin: quantification via resonance Raman spectrophotometry and autofluorescence imaging. Jpn J Ophthalmol. 2012 Sep; 56(5):488-96.


(22) Landrum J, Bone R, Mendez V et al: Comparison of dietary supplementation with lutein diacetate and lutein: a pilot study of the effects on serum and macular pigment. Acta Biochim Pol. 2012; 59(1):167-9.


(23) Graydon R, Hogg RE, Chakravarthy U et al: The effect of lutein- and zeaxanthin-rich foods v. supplements on macular pigment level and serological markers of endothelial activation, inflammation and oxidation: pilot studies in healthy volunteers. Br J Nutr. 2012 Jul; 108(2):334-42.


(24) Piermarocchi S, Saviano S, Parisi V et al: Carotenoids in Age-related Maculopathy Italian Study (CARMIS): two-year results of a randomized study. Eur J Ophthalmol. 2012 Mar-Apr; 22(2):216-25.


(25) Thyagarajan B, A Meyer K, Smith LJ et al: Serum carotenoid concentrations predict lung function evolution in young adults: the Coronary Artery Risk Development in Young Adults (CARDIA) study. Am J Clin Nutr. 2011 Nov; 94(5):1211-8.


(26) Shvetsov YB, Hernandez BY, Wilkens LR et al: Plasma micronutrients and the acquisition and clearance of anal human papillomavirus infection: the Hawaii HPV cohort study. Cancer Res. 2010 Dec 1; 70(23):9787-97.


(27) Berson EL, Rosner B, Sandberg M et al: Clinical trial of lutein in patients with retinitis pigmentosa receiving vitamin A. Arch Ophthalmol. 2010 Apr; 128(4):403-11.


(28) Perrone S, Longini M, Marzocchi B et al: Effects of lutein on oxidative stress in the term newborn: a pilot study. Neonatology. 2010; 97(1):36-40.


(29) Cho H, Kim MK, Lee JK et al: Relationship of serum antioxidant micronutrients and sociodemographic factors to cervical neoplasia: a case-control study. Clin Chem Lab Med. 2009; 47(8):1005-12.


(30) Ma L, Lin XM, Zou ZY et al: A 12-week lutein supplementation improves visual function in Chinese people with long- term computer display light exposure. Br J Nutr. 2009 Jul; 102(2):186-90.


(31) McCall DO, McGartland CP, McKinley MC et al: Dietary intake of fruits and vegetables improves microvascular function in hypertensive subjects in a dose-dependent manner. Circulation. 2009 Apr 28; 119(16):2153-60.


(32) Mignone LI, Giovannucci E, Newcomb PA et al: Dietary carotenoids and the risk of invasive breast cancer. Int J Cancer. 2009 Jun 15; 124(12):2929-37.


(33) Johnson EJ, McDonald K, Caldarella SM et al: Cognitive findings of an exploratory trial of docosahexaenoic acid and lutein supplementation in older women. Nutr Neurosci. 2008 Apr; 11(2):75-83.


(34) Johnson EJ, Chung HY, Caldarella SM et al: The influence of supplemental lutein and docosahexaenoic acid on serum, lipoproteins, and macular pigmentation. Am J Clin Nutr. 2008 May; 87(5):1521-9.


(35) Dherani M, Murthy GV, Gupta SK et al: Blood levels of vitamin C, carotenoids and retinol are inversely associated with cataract in a North Indian population. Invest Ophthalmol Vis Sci. 2008 Aug; 49(8):3328-35.


(36) Moeller SM, Voland R, Tinker L et al: Associations between age-related nuclear cataract and lutein and zeaxanthin in the diet and serum in the Carotenoids in the Age-Related Eye Disease Study, an Ancillary Study of the Women’s Health Initiative. Arch Ophthalmol. 2008 Mar; 126(3):354-64.


(37) Palombo P, Fabrizi G, Ruocco V et al: Beneficial long-term effects of combined oral/topical antioxidant treatment with the carotenoids lutein and zeaxanthin on human skin: a double-blind, placebo-controlled study. Skin Pharmacol Physiol. 2007; 20(4):199-210.


(38) Hozawa A, Jacobs DR Jr, Steffes MW et al: Relationships of circulating carotenoid concentrations with several markers of inflammation, oxidative stress, and endothelial dysfunction: the Coronary Artery Risk Development in Young Adults (CARDIA)/Young Adult Longitudinal Trends in Antioxidants (YALTA) study. Clin Chem. 2007 Mar; 53(3):447-55.


(39) Zhao X, Aldini G, Johnson EJ et al: Modification of lymphocyte DNA damage by carotenoid supplementation in postmenopausal women. Am J Clin Nutr. 2006 Jan; 83(1):163-9.


(40) Kato I, Ren J, Visscher DW et al: Nutritional predictors for cellular nipple aspirate fluid: Nutrition and Breast Health Study. Breast Cancer Res Treat. 2006 May; 97(1):33-9.


(41) Coyne T, Ibiebele TI, Baade PD et al: Diabetes mellitus and serum carotenoids: findings of a population-based study in Queensland, Australia. Am J Clin Nutr. 2005 Sep; 82(3):685-93.


(42) Morganti P, Fabrizi G, Bruno C: Protective effects of oral antioxidants on skin and eye function. Skinmed. 2004 Nov-Dec; 3(6):310-6.


(43) Richer S, Stiles W, Statkute L et al: Double-masked, placebo-controlled, randomized trial of lutein and antioxidant supplementation in the intervention of atrophic age-related macular degeneration: the Veterans LAST study (Lutein Antioxidant Supplementation Trial). Optometry. 2004 Apr; 75(4):216-30.